The author presents the results of IIF examinations for pemphigus, pemphigoid antibodies and antinuclear antibodies (ANA) on the epithelium of the human palatal tonsil obtained by tonsillectomy in patients with chronic hypertrophic tonsillitis. Tonsil epithelium is more sensitive to intercellular antibodies (IC Ab), and antibodies of the basal membrane zone (BMZ Ab) than sample tissue of the monkey esophagus, while its reaction to ANA is the same or even weaker than monkey esophagus.