PATHOBIOLOGY OF LIPOPOLYSACCHARIDE
作者:
PhilipR. Mayeux,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1997)
卷期:
Volume 51,
issue 5
页码: 415-435
ISSN:0098-4108
年代: 1997
DOI:10.1080/00984109708984034
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Lipopolysaccharide is a component of the gram-negative bacterial cell wall that is responsible for 25,000-50,000 deaths in the United States each year. The sequelae of gram-negative infection and septicemia leading to death include fever, hypotension with inadequate tissue perfusion, and disseminated intravascular coagulation. It is clear that different cell types respond differently to lipopolysaccharide. Furthermore, various autacoids and cytokines are released that can affect cellular function even in cell types that do not recognize lipopolysaccharide. Despite advances made in the etiology of septic shock and organ failure, therapy is still for the most part supportive and largely ineffective. The aim of this review is to summarize the current understanding of the role of lipopolysaccharide in the development of septicemia by examining signal transduction and therapeutic approaches.
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