Folate antagonism following teratogenic exposure to diphenylhydantoin
作者:
Michael L. Netzloff,
Richard R. Streiff,
Jaime L. Frias,
Owen M. Rennert,
期刊:
Teratology
(WILEY Available online 1979)
卷期:
Volume 19,
issue 1
页码: 45-49
ISSN:0040-3709
年代: 1979
DOI:10.1002/tera.1420190108
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractPrevious studies have reported indirect evidence for the mediation of folate antagonism in the induction of malformations by diphenylhydantoin. We have demonstrated that a teratogenic regimen of folate‐deficiency and antagonism using 9‐methyl PGA in the rat produces significantly decreased rates of oxygen consumption in the maldeveloping embryos. The present study reports similar reductions in oxygen uptake by mouse embryos from mothers treated with teratogenic doses of diphenylhydantoin, and documents a significant depression of the actual folate levels in such embryos. The differences are less significant with lower doses of diphenylhydantoin, and do not occur with a nonteratogenic d
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