Procainamide Interference with Liquid Chromatography of Theophylline in Serum
作者:
Athan,
Marion Lawrence,
Lesko Christine,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1981)
卷期:
Volume 3,
issue 1
页码: 107-108
ISSN:0163-4356
年代: 1981
出版商: OVID
关键词: Theophylline;High pressure liquid chromatography;Therapeutic drug monitoring;Procainamide
数据来源: OVID
摘要:
We describe potential interference of procainamide with our high pressure liquid chromatography procedure for assaying theophylline (similar to that given by Orcutt et al.). In participating in the AACC-TDM quality-control program, we discovered procainamide interference on a column dedicated to theophylline and acetaminophen serum analyses. Following attempts at rejuvenation, this 7-month-old column was replaced with a new one, which gave base-line separation of theophylline and procainamide with no difficulty. We recommend close attention to the aging characteristics of columns and participation in a quality-control program.
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