Thiaproline Reduces Glomerular Basement Membrane Thickness and Collagen Accumulation in the db/db Mouse
作者:
Barbara Lubec,
A. Rokitansky,
M. Hayde,
C. Aufricht,
U. Wagner,
W.R. Mallinger,
H. Höger,
G. Lubec,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 66,
issue 3
页码: 333-336
ISSN:1660-8151
年代: 1994
DOI:10.1159/000187832
出版商: S. Karger AG
关键词: Thiaproline;Basement membrane;Glomerular;Collagen;db/db mouse;Diabetes
数据来源: Karger
摘要:
Glomerular basement membrane thickening and mesangial expansion are the main pathological features in diabetic nephropathy – glomerulosclerosis with the biochemical correlate of increased collagen accumulation. We studied a new principle to reduce collagen accumulation in the glomerulus: thiaproline, known to inhibit protein synthesis by blocking the elongation, led in our studies to a morphological reduction of the glomerular basement membrane thickening and to a decreased collagen content. As the thiaproline analogue is incorporated into collagen, the mechanism of increased degradation of the modified collagen is being discusse
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