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Nonsteroidal antiestrogens: Their biological effects and potential mechanisms of action

 

作者: V. Craig Jordan,   CliveJ. Dix,   KarenE. Naylor,   Graham Prestwich,   Linda Rowsby,  

 

期刊: Journal of Toxicology and Environmental Health  （Taylor Available online 1978）
卷期: Volume 4, issue 2-3  

页码: 363-390

 

ISSN:0098-4108

 

年代: 1978

 

DOI:10.1080/15287397809529666

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

The uterotropic and ontiuterotropic effects of a variety of structural derivatives of the nonsteroidal antiestrogen tamoxifen have been determined in the rat and the mouse. One derivative, monohydroxytamoxifen, was found to be a potent antiestrogen in the rat, with a high affinity for the estrogen receptor.

 

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