Inhibition of Renal Creatinine Secretion by Cimetidine in Humans
作者:
Ellen Burgess,
Andrew Blair,
Kenneth Krichman,
Ralph E. Cutler,
期刊:
Kidney and Blood Pressure Research
(Karger Available online 1982)
卷期:
Volume 5,
issue 1
页码: 27-30
ISSN:1420-4096
年代: 1982
DOI:10.1159/000172836
出版商: S. Karger AG
关键词: Cimetidine;Creatinine secretion
数据来源: Karger
摘要:
The renal clearance of inulin (Clin), 14C-creatinine (Cl14C.cr) and endogenous creatinine (Clcr) were measured in 6 healthy subjects before and after a single intravenous bolus of cimetidine (5 mg/kg). The initial Cli4C.cr/Clin ratio (mean ± SD) was 1.68 ± 0.17; this fell to a nadir of 1.35 ± 0.18 soon after cimetidine was infused and rose again as the drug was excreted. This is the first cationic drug to show substantial inhibition of tubular secretion of creatinine in huma
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