Evidence for Altered Vascular Reactivity in Sodium‐Sensitive Young Subjects with Borderline Hypertension
作者:
JAY SULLIVAN,
THOMAS RATTS,
STEVEN REED,
AHMAD BANNA,
JOHN RIDDLE,
COLLIER JORDAN,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1984)
卷期:
Volume 288,
issue 2
页码: 65-74
ISSN:0002-9629
年代: 1984
出版商: OVID
关键词: Hypertension;Sodium;Vascular resistance;Diets;Cardiac output;Blood pressure;Echocardiography;Plethysmography;Renin;Heart size
数据来源: OVID
摘要:
To assess mechanisms associated with the pressor effects of a high sodium diet in susceptible individuals, the hemodynamic and hormonal effects of sodium depletion and repletion were studied in 33 normal subjects and 30 subjects with borderline hypertension. The hypertensive group had significantly higher mean arterial pressure, weight, hematocrit, and upright plasma renin activity. Forearm hemodynamics were measured during periods of ad lib diet, 10 mEq, and 200 mEq sodium diet. The fall in forearm resistance during reactive hyperemia was inversely related to mean arterial pressure at rest (R = .400, p < .005) and rose significantly in hypertensive subjects during salt depletion, 39±3.6 to 61±6.1 mmHg/ml/min/100 g (p < .05).Sodium sensitivity in either normotensive or borderline hypertensive subjects was defined as an increase in mean blood pressure of more than 5% when sodium repleted. The individuals who were sodium sensitive had a higher forearm vascular resistance during sodium depletion than those who were sodium resistant, 67±10.5 versus 45±4.1 mm/ml/min/100 g (p < .03). We conclude that young individuals with borderline hypertension already have alterations in vascular reactivity. This trait is shared by normotensive individuals whose blood pressure rises in response to sodium.
点击下载:
PDF
(814KB)
返 回