Association analysis of the proneurotensin gene and bipolar disorder
作者:
J. Austin,
B. Hoogendoorn,
P. Buckland,
I. Jones,
F. McCandless,
N. Williams,
F. Middle,
M. Owen,
N. Craddock,
M. O'Donovan,
期刊:
Psychiatric Genetics
(OVID Available online 2000)
卷期:
Volume 10,
issue 1
页码: 51-54
ISSN:0955-8829
年代: 2000
出版商: OVID
关键词: polymorphism;mutation;gene;schizophrenia;bipolar disorder
数据来源: OVID
摘要:
&NA;Neurotensin (NT) localizes within dopaminergic neurones in the mesocortical, mesolimbic and nigrostriatal systems, and it is now clear that NT can selectively modulate dopaminergic neurotransmission. It has therefore been proposed that altered NT function might contribute to the pathogenesis of neuropsychiatric disorders in which disordered dopaminergic neurotransmission is suspected. We have previously screened the gene encoding NT in a sample of schizophrenic and bipolar subjects, and identified three sequence variants. These have now been tested for association with bipolar disorder using a case‐control sample of unrelated bipolar subjects and matched controls. No evidence for association was found, and our data therefore suggest that sequence variation in this gene does not make an important contribution to susceptibility to bipolar disorder.
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