The relevance of glial monoamine oxidase‐B and polyamines to the action of selegiline in parkinson's disease
作者:
M. B. H. Youdim,
P. Riederer,
期刊:
Movement Disorders
(WILEY Available online 1993)
卷期:
Volume 8,
issue S1
页码: 8-13
ISSN:0885-3185
年代: 1993
DOI:10.1002/mds.870080504
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: diamines;polyamines;monoamine oxidase‐B substrate;selegiline (L‐deprenyl);NMDA‐glutamate receptor;parkinson's disease
数据来源: WILEY
摘要:
AbstractDopamine and 2‐phenylethylamine levels in striatal tissue are known to be increased after administration of selegiline (L‐deprenyl), but it is still difficult to explain why this treatment induces longevity or dopaminergic neuroprotection in Parkinson's disease. In the absence of significant polyamine or diamine oxidase activities in human brain, polyamines and histamine are detoxified byN‐acetylation and methylation, respectively. Methylhistamine as well asN‐acetylated polyamine derivatives are selective substrates for monoamine oxidase type B (MAO‐B). Theoretically at least, MAO‐B inhibition by selegiline could result in the increase in the levels of polyamines and theirN‐acetyl derivatives. This could have significance for the action of selegiline in Parkinson's disease, as overactive corticostriatal glutaminergic function has been implicated in the degeneration of nigrostriatal dopamine neurons, and polyamines are potent modulators of the excitotoxic NMDA (N‐methyl‐D‐aspartate)‐gluta
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