Bioavailability of Levodopa after Consumption ofVicia fabaSeedlings by Parkinsonian Patients and Control Subjects
作者:
Y. Vered,
J. Rabey,
D. Palevitch,
I. Grosskopf,
A. Harsat,
A. Yanowski,
H. Shabtai,
E. Graff,
期刊:
Clinical Neuropharmacology
(OVID Available online 1994)
卷期:
Volume 17,
issue 2
页码: 138-146
ISSN:0362-5664
年代: 1994
出版商: OVID
关键词: Vicia faba;Parkinson's disease;Levodopa
数据来源: OVID
摘要:
Recently, we have shown that ingestion ofVicia fababeans improved substantially the clinical features in parkinsonian patients. However, the supply of the beans is season-dependent and their digestion can be quite unpleasant due to flatulence. In the present study, we verified that the L-Dopa content ofV. fabaseedlings is 20-fold higher than that of the fruit. Moreover, the germination of the seedlings is easy and not season-dependent, and their ingestion does not cause any adverse digestive effects. In the present study, seven Parkinson's disease (PD) patients and nine healthy controls ingestedV. fabaseedlings. Plasma L-Dopa and dihydroxyphenylacetic acid (DOPAC) levels were measured by a high performance liquid chromatography with electrochemical detection (HPLC-ECD) method. Plasma L-Dopa increased in both populations, and a substantial clinical improvement was observed in the patients according to the Webster scale.Vicia fabaseedling ingestion is a useful tool in the treatment of PD patients, especially those in low-income societies where limited resources do not allow the purchase or manufacture of expensive drugs. This treatment might also appeal to those people who prefer natural treatment in PD and in other conditions for which L-Dopa is prescribed.
点击下载:
PDF
(408KB)
返 回