The Influence of Pefloxacine on Experimental Adriamycin-Induced Nephrotic Syndrome in Rats
作者:
ZimaTomÁŠ,
TesařVladimÍR,
RychlíkIvan,
NěmečekKarel,
PoledneRudolf,
TěmínováJana,
ŠtípekStanislav,
MertaMiroslav,
期刊:
Renal Failure
(Taylor Available online 1996)
卷期:
Volume 18,
issue 2
页码: 195-199
ISSN:0886-022X
年代: 1996
DOI:10.3109/08860229609052789
出版商: Taylor&Francis
关键词: Adriamycin nephropathy;Nephrotic syndrome;Pefloxacine;Rat
数据来源: Taylor
摘要:
Initial reports on antiproteinuric effect of pefloxacine in small groups of patients with minimal-change nephropathy (MCN) and focal and segmental glomerulosclerosis (FSGS) have not been confirmed in other papers. To assess its antiproteinuric effect in experimental animals we administered pefloxacine to rats with adriamycin nephropathy showing morphological changes resembling human minimal-change disease or focal segmental glomerulosclerosis, and clinically with full-blown nephrotic syndrome. Pefloxacine treatment was at least partially effective in preventing further increase of proteinuria in rats with adriamycin nephropathy. The mechanism of this effect remains unclear and deserves further studies concentrating on the glomerular cytokine network and glomerular production of reactive oxygen species.
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