Continuous Infusion 5-Fluorouracil with Bolus Adriamycin and Mitomycin and Low-Dose Cisplatin (FAMP) in the Treatment of Metastatic Gastric Carcinoma: An Evaluation of Efficacy and Toxicity
作者:
RaschkoJames W.,
JohnsonElizabeth A.,
UenoWinston,
WoolleyPaul V.,
TreatJoseph,
期刊:
Cancer Investigation
(Taylor Available online 1991)
卷期:
Volume 9,
issue 1
页码: 49-51
ISSN:0735-7907
年代: 1991
DOI:10.3109/07357909109032799
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractA pilot study was performed to evaluate the feasability of administering prolonged continuous infusion 5-fluorouracil with multiple bolus chemotherapeutic agents. Twelve patients with advanced measurable gastric carcinoma were treated with a combination chemotherapy program of continuous infusion 5-fluorouracil, bolus Adriamycin, mitomycin C, and low-dose cisplatin (FAMP). Responses were observed in 5 patients (2 complete and 3 partial). Observed toxicities included leukopenia, thrombocytopenia, mucositis, and hand-foot syndrome. Although the FAMP regimen has activity in advanced gastric carcinoma, the number of patients evaluated was small and significant improvement over currently available regimens could not be demonstrated. Evaluation of toxicities indicates that bolus administration of multiple agents (specifically, Adriamycin, mitomycin C, and cisplatin) can be used in conjunction with continuously infused 5-fluorouracil without excessive toxicity.
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