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Surface Properties of Cultured Endothelial Cells

 

作者: C. Busch,   C. Ljungman,   C.-M. Heldin,   E. Waskson,   B. Öbrink,  

 

期刊: Pathophysiology of Haemostasis and Thrombosis  （Karger Available online 1979）
卷期: Volume 8, issue 3-5  

页码: 142-148

 

ISSN:1424-8832

 

年代: 1979

 

DOI:10.1159/000214306

 

出版商: S. Karger AG

 

关键词: Endothelial cells;Surface;Glycosaminoglycans;Heparin;Platelets;Platelet factor IV;Coagulation factors

 

数据来源: Karger

 

摘要:

Vascular endothelial cells (EC) are non-thrombogenic. The basis for this property is still essentially unknown. This paper summarizes our previous studies on EC associated glycosaminoglycans and on the specific binding of heparin to EC and describes the preventive effect of heparin sulphate (HS) on platelet adhesion to collagen; attempts to affect the binding of platelets to EC by specific removal of endogenous HS were, however, unsuccessful. The possible importance of EC surface HS for interactions with coagulation factors is discussed.

 

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