A computer simulation is performed to compare confidence regions arising from Fie1ler's theorem and approximate large sample intervals in estimating the point of extremum in quadratic regression. In addition, two designs, one of which is motivated by optimal design theory, are compared. These comparisons are made by examining the confidence level and accuracy of the regions, as well as the concentration of the standard point estimator, in a variety of settings. The results have implications for the more general problem of estimating a ratio of linear combinations in the general linear model.