Systemic nitroglycerin increases nNOS levels in rat trigeminal nucleus caudalis
作者:
Arpad Pardutz,
Istvan Krizbai,
Sylvie Multon,
Laszlo Vecsei,
Jean Schoenen,
期刊:
NeuroReport
(OVID Available online 2000)
卷期:
Volume 11,
issue 14
页码: 3071-3075
ISSN:0959-4965
年代: 2000
出版商: OVID
关键词: Migraine;Nitric oxide synthase;Nitroglycerin;Trigeminovascular system
数据来源: OVID
摘要:
Systemic administration of nitroglycerin, a nitric oxide donor, triggers in migraineurs a delayed attack of unknown mechanisms. Subcutaneous nitroglycerin (10 mg/kg) produced a significant increase of nitric oxide synthase (NOS)- and c-fos-immunoreactive neurons in the cervical part of trigeminal nucleus caudalis in rats after 4 h. This effect was not observed in the thoracic dorsal horn. Similar increase of NOS and c-fos was obtained in the brain stem after a somatic nociceptive stimulus, i.e. on the side of the formalin injection in the lip. Nitric oxide is thus able to increase NOS availability in second order nociceptive trigeminal neurons, which may be relevant for central sensitization and the understanding of its effect in migraine.
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