Efficacy of Topical Dimetindene in Experimentally Induced Pruritus and Weal and Flare Reactions
作者:
L.R. Lever,
S. Hill,
P.J. Dykes,
R. Marks,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1991)
卷期:
Volume 4,
issue 2
页码: 109-112
ISSN:1660-5527
年代: 1991
DOI:10.1159/000210933
出版商: S. Karger AG
关键词: Dimetindene;Antihistamine;Histamine
数据来源: Karger
摘要:
Double-blind, placebo-controlled studies were performed to assess the effect of 0.1 % dimetindene gel on the itch threshold to intracutaneous histamine and on the weal and flare reaction after intracutaneous injection of histamine in normal volunteer subjects. Treatment of the forearm skin in 20 volunteers resulted in an increase in itch threshold with dimetindene gel compared to placebo. Treatment of the forearm skin with dimetindene gel in 32 volunteers had no significant effect on weal thickness in subjects treated for 10, 30 or 60 min, but there was a significant reduction in weal thickness in those subjects treated for 120 min. Topical dimetindene may be of value in treating conditions mediated through histamine release.
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