Biochemistry of Natural Proteinase Inhibitors
作者:
Harald Tschesche,
期刊:
Angewandte Chemie International Edition in English
(WILEY Available online 1974)
卷期:
Volume 13,
issue 1
页码: 10-28
ISSN:0570-0833
年代: 1974
DOI:10.1002/anie.197400101
出版商: Hüthig&Wepf Verlag
关键词: Inhibitors;Inhibitors
数据来源: WILEY
摘要:
AbstractThe natural inhibitors of proteolytic enzymes are proteins. These inhibitors associate reversibly with the enzymes to form stoichiometric protein‐protein complexes, in which substrate‐analogous association at the active center of the enzyme results in competitive inhibition of all catalytic functions. The very widespread occurrence of inhibitors in the animal and plant kingdoms underlines their biological importance in the intermediate metabolism, which can be understood as an extension of the possibilities for temporary and local limitations of enzyme activities. Existing knowledge includes a series of covalent structures, detailed kinetic data on the reversible protein‐protein interaction, the processes involved in inactivation, and chemical methods for the modification of these proteins. Early X‐ray structural data for an inhibitor and its enzyme complex provide an insight into the molecular structure of the latter and the interactions involved in the association to form the
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