Comparison of Chiral Separations in Capillary Zone Electrophoresis with Other Methods*
作者:
HaleemJ. Issaq,
期刊:
Instrumentation Science & Technology
(Taylor Available online 1994)
卷期:
Volume 22,
issue 2
页码: 119-149
ISSN:1073-9149
年代: 1994
DOI:10.1080/10739149408001183
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Capillary zone electrophoresis (CZE) is an efficient microseparation technique that can be used for the separation of small as well as large biomolecules. The use of micelles in the buffer makes CZE an acceptable technique for the resolution of charged and neutral molecules. The separation of chiral compounds is an important aspect of the pharmaceutical industry, synthetic organic chemistry and other areas. Optical isomers can be separated from each other using high pressure liquid chromatography (HPLC) and capillary gas chromatography (CGC), however, each of these techniques has its limitations. CGC and HPLC require a chiral column, which is costly, CZE does not. CZE has the highest efficiency and chiral separations are achieved by adding a modifier to the buffer that facilitates the separation of optical isomers.
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