Chapter 5: Pathogenetic mechanisms of selected late effects: Initiation of non‐neoplastic late effects: The role of endothelium and connective tissue
作者:
Mohi Rezvani,
John W. Hopewell,
Mike E. C. Robbins,
期刊:
STEM CELLS
(WILEY Available online 1995)
卷期:
Volume 13,
issue S1
页码: 248-256
ISSN:1066-5099
年代: 1995
DOI:10.1002/stem.5530130730
出版商: John Wiley&Sons, Ltd.
关键词: Radiation;Late effect;Endothelium;Skin;Kidney;Central nervous system;Cytokines
数据来源: WILEY
摘要:
AbstractWhile early radiation lesions might be a direct consequence of parenchymal cell loss, late‐radiation injury most probably develops as a consequence of functional perturbations that may involve both parenchymal and nonparenchymal elements. Damage to blood vessels and consequent perturbations in blood flow and endothelial physiology play an important role in the development of late effects. The development of late‐radiation damage has been studied in three different tissue systems: the skin, kidney and central nervous system. The results suggested that damage to vascular tissue played a major role in the development of radiation‐induced late ef
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