HPLC RETENTION AND INCLUSION OF IMIDAZOLE DERIVATIVES USING HYDROXYPROPYL-β-CYCLODEXTRIN AS A MOBILE PHASE ADDITIVE
作者:
N. Morin,
S. Cornet,
C. Guinchard,
J.-C. Rouland,
Y.C. Guillaume,
期刊:
Journal of Liquid Chromatography & Related Technologies
(Taylor Available online 2000)
卷期:
Volume 23,
issue 5
页码: 727-739
ISSN:1082-6076
年代: 2000
DOI:10.1081/JLC-100101485
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Using the results of high performance liquid chromatography (HPLC), this paper investigates the separation and inclusion of a series of weakly polar imidazole derivatives, with hydroxypropylβ -cyclodextrin (HP-β-CD) in the mobile phase over a wide range of column temperatures.These compounds are used for the treatment of onychomycosis. Gibbs Helmholtz parameters (Δ(ΔH) and Δ(ΔS)) of two adjacent imidazole peak on a chromatogram were determined from the graph of the logarithm of the separation factor,α, against the reciprocal of the temperature. A temperature dependent reversal of the elution order between a pair of imidazole derivatives was studied.
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