Total syntheses of the slime mold alkaloid arcyriacyanin A
作者:
Michael Brenner,
Guido Mayer,
Andreas Terpin,
Wolfgang Steglich,
期刊:
Chemistry – A European Journal
(WILEY Available online 1997)
卷期:
Volume 3,
issue 1
页码: 70-74
ISSN:0947-6539
年代: 1997
DOI:10.1002/chem.19970030112
出版商: WILEY‐VCH Verlag
关键词: alkaloids;Heck reactions;heterocycles;indoles;total syntheses
数据来源: WILEY
摘要:
AbstractArcyriacyanin A (1) has been synthesized by three different routes. In the first synthesis the bisbromomagnesium salt of 2,4′‐biindole (5) was treated with dibromomaleimide (6) to yield arcyriacyanin A (1). The second approach used an intramolecular Heck reaction for the cyclization of a 4‐(triflyloxy)arcyriarubin8toN‐methylarcyriacyanin A (2). Thirdly, compound2was obtained by a domino Heck reaction between 3‐bromo‐4‐[1‐(tert‐butoxycarbonyl)indol‐3‐yl]‐1‐methylmaleimide (9) and 4‐bromoindole (10). TheN‐methyl derivative2could be transformed into arcyriacya
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