Aging-Related Changes in Retrograde Amnesia for Mice
作者:
Walter B. Essman,
期刊:
Gerontology
(Karger Available online 1982)
卷期:
Volume 28,
issue 5
页码: 303-313
ISSN:0304-324X
年代: 1982
DOI:10.1159/000212547
出版商: S. Karger AG
关键词: Mice;Brain;Memory consolidation;Serotonin;Protein synthesis
数据来源: Karger
摘要:
Aging mice showed a retrograde amnesia for passive avoidance behavior when a single electroconvulsive shock (ECS) was given at post-training intervals up to 1 h, whereas adult mice showed no significant amnesia when ECS was given 10 min or more after training. Catecholamines (norepinephrine and dopamine), but not serotonin (5-HT) changed with aging in the several brain regions, but only 5-HT was significantly changed (elevated) by ECS. Protein synthesis was significantly inhibited by ECS, notably in limbic structures. The increased susceptibility of aging mice to the amnesic effect of ECS could be related to aging-related changes in the rate of memory consolidation or to the duration of neural chemical changes that disrupt processes such as consolidation, storage, and/or retrieval of the memory trace.
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