Stimulation of oligodendrocytes by extracts from astrocyte‐enriched cultures
作者:
S. Bhat,
S. E. Pfeiffer,
期刊:
Journal of Neuroscience Research
(WILEY Available online 1986)
卷期:
Volume 15,
issue 1
页码: 19-27
ISSN:0360-4012
年代: 1986
DOI:10.1002/jnr.490150103
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: oligodendrocytes;astrocytes;myelinogenesis;growth factors
数据来源: WILEY
摘要:
AbstractA soluble, heat‐labile, trypson‐sensitive factor present in extracts of astrocyteenriched cultures enhances the expression of myelination‐associated events in rat brain cultures enriched in oligodendrocytes. Both the number of oligodendrocytes detected by immunofluorescence microscopy and the levels of biochemical activities associated with oligodendrocyte differentiation increased in the cultures in respose to the extract in a time‐ and concentration‐dependent fashion. The possible significance of these studies of normal oligodendrocytes function, and thus myelination, is
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