Low‐grade Glial Tumors in Basal Ganglia and ThalamusNatural History and Biological Reappraisal
作者:
Angelo Franzini,
Filippo Leocata,
Laura Cajola,
Domenico Servello,
Antonio Allegranza,
Giovanni Broggi,
期刊:
Neurosurgery
(OVID Available online 1994)
卷期:
Volume 35,
issue 5
页码: 817-821
ISSN:0148-396X
年代: 1994
出版商: OVID
关键词: Cell kinetics;Low-grade glial tumors;Stereotactic biopsy
数据来源: OVID
摘要:
THE NATURAL HISTORY of 70 patients affected by low-grade astrocytomas was recorded after the histological diagnosis was obtained by serial stereotactic biopsy. Forty-three percent of these patients died within 3 years. The value of cell kinetics assessment at the time of stereotactic biopsy was investigated, and the labeling index percent may be considered the most accurate prognostic factor in these histologically homogeneous astrocytomas. It has been confirmed that the young age of patients predicts a more favorable course, but the value of this also seems to be linked to and dependent on cell kinetics. These data are discussed in view of the opportunity to perform more aggressive “cytoreductive” treatments in deep brain tumors when these indices support an expected poor prognosis.
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