Platelet-Derived Growth Factor is AngiogenicIn Vivo
作者:
RisauWerner,
DrexlerHannes,
MironovVladimir,
SmitsAnja,
SiegbahnAgneta,
FunaKeiko,
HenrikCarl,
期刊:
Growth Factors
(Taylor Available online 1992)
卷期:
Volume 7,
issue 4
页码: 261-266
ISSN:0897-7194
年代: 1992
DOI:10.3109/08977199209046408
出版商: Taylor&Francis
关键词: Platelet-derived growth factor;angiogenesis;chemotaxis;endothelial cells
数据来源: Taylor
摘要:
AbstractPDGF receptors have recently been found to be expressed in microvascular endotheliumin vivounder circumstances of endothelial cell activation and angiogenesis suggesting that PDGF may have a direct effect on endothelial cells. We have tested the angiogenic activity of PDGF-AA and -BB homodimers in the chick chorioallantoic membranein vivo.PDGF-BB was found to consistently induce an angiogenic response whereas PDGF-AA was less active. Morphological analyses revealed that there was little inflammation associated with this response but an increase in vessel density suggested a direct effect of PDGF on embryonic chorioallantoic endothelial cells.In vitro, PDGF-BB was found to be more potent than PDGF-AA in stimulating the chemotaxis of rat brain capillary endothelial cells. This is consistent with a direct effect of PDGF on endothelial cells. Thus, this novel angiogenic activity of PDGF has implications for several developmental and pathological events in which PDGF, particularly the B-chain, is expressed.
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