Pomelo-induced increase in the blood level of tacrolimus in a renal transplant patient
作者:
Kanoko Egashira,
Etsuko Fukuda,
Takayuki Onga,
Yasuo Yogi,
Fukuzou Matsuya,
Noriko Koyabu,
Hisakazu Ohtani,
Yasufumi Sawada,
期刊:
Transplantation
(OVID Available online 2003)
卷期:
Volume 75,
issue 7
页码: 1057-1057
ISSN:0041-1337
年代: 2003
出版商: OVID
数据来源: OVID
摘要:
Background.Tacrolimus, an immunosuppressive agent, is widely used in patients after transplantation to prevent allograft rejection. Because tacrolimus has a narrow therapeutic range, it is essential to carefully control the blood level. It has been demonstrated that tacrolimus is metabolized mainly by cytochrome P-450 (CYP) 3A4, and that tacrolimus is a substrate of P-glycoprotein.Methods.This article reports a case of considerable increase in the blood level of tacrolimus after the intake of pomelo in a renal transplant recipient.Results.Pomelo may increase the blood concentration of tacrolimus by inhibiting CYP 3A4, P-glycoprotein, or both.Conclusions.Patients taking drugs such as tacrolimus or cyclosporine, which have their kinetics affected by grapefruit juice, should avoid pomelo and other grapefruit-related citrus fruits.
点击下载:
PDF
(72KB)
返 回