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The Study of HLA, ICA and Autoantibodies in Japanese Type 1 Diabetes Mellitus

 

作者: Kaichi Kida,   Goto Mimura,   Tetsuro Kobayashi,   Koichi Nakamura,   Shunro Sonoda,   Hiroo Inoue,   Kimiyoshi Tsuji,  

 

期刊: Pediatrics International  （WILEY Available online 1987）
卷期: Volume 29, issue 3  

页码: 345-348

 

ISSN:1328-8067

 

年代: 1987

 

DOI:10.1111/j.1442-200X.1987.tb00328.x

 

出版商: Blackwell Publishing Ltd

 

关键词: HLA;ICA;Type 1 diabetes;Autoantibodies

 

数据来源: WILEY

 

摘要:

AbstractHLA, ICA (islet cell antibody) and autoantibodies were studied in 65 Japanese patients with type 1 diabetes mellitus to elucidate the existence of immuno‐genetic heterogeneity. Patients with autoantibodies had increased frequencies of HLA DRw9 antigen and of HLA haplotype of Bw61‐DRw9, and a slow decay of ICA, while patients without autoantibodies had increased frequencies of HLA DR4 antigen and of HLA haplotype of Bw54‐DR4, and a rapid decay of ICA. These findings support the concept of immunogenetic heterogeneity in Japanese type 1 diabetes mel

 

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