Modulation of Bcl‐2 expressiona potential component of estrogen protection in NT2 neurons
作者:
Cherie Singer,
Keith Rogers,
Daniel Dorsa,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 11
页码: 2565-2568
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Bcl-2;Estrogen;Glutamate;Neuroprotection;Oxidative stress
数据来源: OVID
摘要:
EUROPROTECTIVE effects of estrogen have been demonstrated against a variety of cytotoxic insults. We present data here addressing a possible mechanism of estrogen neuroprotection in the human teratocarcinoma cell line NT2 terminally differentiated to a neuronal phenotype. Cell death induced by H2O2or glutamate results in a dose-dependent cell death of NT2 neurons, while 24 h of estrogen pretreatment significantly enhances neuronal viability. Bcl-2 expression has been shown to reduce oxidative stress and prevent cell death. In NT2 neurons, Bcl-2 levels are dramatically elevated upon differentiation and are further enhanced with estrogen treatment. These results suggest that neuroprotective effects of estrogen may be related to increases in Bcl-2 expression.
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