Activation of immediate early genes after acute stress
作者:
Steven Schreiber,
Georges Tocco,
Tracey Shors,
Richard Thompson,
期刊:
NeuroReport
(OVID Available online 1991)
卷期:
Volume 2,
issue 1
页码: 17-20
ISSN:0959-4965
年代: 1991
出版商: OVID
关键词: Immediate early genes;induction;Acute stress;In-situ hybridization
数据来源: OVID
摘要:
WE usedin-situhybridization to study the effect of acute stress on induction of the immediate early genes (IEGs), c-fos and zif/268, in the rat brain. After one hour of restraint plus intermittent tail shock, messenger RNA (mRNA) levels for both genes were significantly increased bilaterally in the neocortex, particularly in layers IV, V and VI, and in the CA1 region of the hippocampus. This regionally-specific response suggests that IEGs may have a role in the mediation of acute stress responses in the central nervous system.
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