Pre‐exposure to alcohol does not sensitize to the rewarding effects of cocaine
作者:
Gwenaëlle Le Pen,
Dominique Duterte-Boucher,
Martine Daoust,
Jean Costentin,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 12
页码: 2887-2891
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Cocaine;Conditioned place preference;Ethanol;Free choice;Individual differences;Rat
数据来源: OVID
摘要:
THE conditioned place preference (CPP) induced by cocaine 2.5mg/kg was measured in rats pre-exposed to ethanol (14 days with only 10% v/v ethanol followed by a free choice between ethanol solution and water for 14 days). Rats were divided according to their alcohol intake during the free choice period into low-drinking (< 3 g/kg per day), intermediate-drinking and high-drinking (> 4 g/kg per day) rats. Cocaine-induced CPP was not modified in high-drinking rats relative to controls. Low-drinking rats had a lower CPP than high-drinking rats and controls. We conclude that pre-exposure to alcohol did not sensitize to the cocaine rewarding effects, and that alcohol low-drinking rats showed the lowest preference for cocaine.
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