AbstractFlow characteristics of a versatile large‐volume flow‐through electrochemical cell, which features exchangeable disk, ring‐disk or microdisk working electrodes, are presented. The cell operates in a radial‐flow thin‐layer, wall‐jet or wall‐tube mode, under amperometric or voltammetric conditions, being therefore suitable for flow analytical techniques, such as high performance liquid chromatography (HPLC) and flow injection analysis (FIA). The operation mode is selected by using the inlet capillary either of a flat or conical nozzle and by suitably adjusting the nozzle‐to‐electrode distance. The cell is equipped with a micrometer screw which allows for adjusting of this distance to be as small as 10 ± 5 μm. The inlet solution stream is centered axially against the working electrode surface. Under radial‐flow thin‐layer conditions, flow‐through detection at a ring‐disk electrode benefits from shielding and collecting properties which are enhanced as compared to those for the rotating ring‐disk electrode conditions. The HPLC extracolumn effects due to detection were determined by the peak variance analysis of a mixture of regio isomers of nitrobenzene derivatives. Despite the large (35mL) geometric cell volume, the effective detection volume of the cell is of the microliter order. Therefore, the cell is suitable for detection both in the analytical and microbore‐column HPLC. Due to the large geometric cell volume, solution composition can be different, under wall‐jet conditions, for detection than that for HPLC separation. Hence,in situpostcolumn modification of the mo