Comprehensive Classification of Symptoms and Signs Reported Among 218 Patients With Acute HIV-1 Infection
作者:
Philippe Vanhems,
Clement Dassa,
Jean Lambert,
David Cooper,
Luc Perrin,
Jeanette Vizzard,
Bernard Hirschel,
Sabine Loës,
Andrew Carr,
Robert Allard,
期刊:
JAIDS Journal of Acquired Immune Deficiency Syndromes
(OVID Available online 1999)
卷期:
Volume 21,
issue 2
页码: 99-106
ISSN:1525-4135
年代: 1999
出版商: OVID
关键词: Acute HIV-1 infection;Diagnosis;Descriptive study;Classification;Factor analysis;Pathogenesis
数据来源: OVID
摘要:
Acute HIV-1 illness presents a wide range of clinical manifestations. We assessed a classification and data reduction of clinical features among 218 patients with acute HIV-1 infection enrolled in four prospective seroincidence studies. Factor analysis allows the definition of eight factors based on groups of symptoms and signs: gastrointestinal transit disturbances, weight loss/abdominal pain, lymphadenopathy, myalgia/arthralgia, neurologic features, constitutional and mucocutaneous features, oral candidiasis, and anorexia/pharyngitis. These groups reflected the main target systems involved at the time of acute HIV-1 disease. Grouping of symptoms and signs based on groups of patients is potentially more informative than observations made on individual patients. It might facilitate diagnosis, suggest pathogenic mechanisms and reduce the number of variables for characterizing acute HIV-1 illness.
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