Paraventricular Lesions Abolish the Stress-Induced Rise in Pituitary Cyclic Adenosine Monophosphate and Attenuate the Increases in Plasma Levels of Proopiomelanocortin-Derived Peptides and Prolactin
作者:
James L. Meyerhoff,
Edward H. Mougey,
Jean Kant,
期刊:
Neuroendocrinology
(Karger Available online 1987)
卷期:
Volume 46,
issue 3
页码: 222-230
ISSN:0028-3835
年代: 1987
DOI:10.1159/000124823
出版商: S. Karger AG
关键词: Stress;Pituitary;Cyclic adenosine monophosphate;Lesions;Paraventricular nucleus;Adrenocorticotropic hormone;Beta-endorphin;Beta-lipotropin;Prolactin;Corticotropin-releasing factor;Vasoactive intestinal peptide;Rat;Proopiomelanocortin;Vasopressin
数据来源: Karger
摘要:
Acute exposure to footshock stress increased the pituitary level of cyclic adenosine monophosphate (AMP) in vivo and sharply increased plasma levels of adrenocorticotropic hormone, β-endorphin and β-lipotrophic hormone, as well as prolactin. Seven days after bilateral lesions of the paraventricular nucleus of the hypothalamus, the pituitary cyclic AMP response to stress was totally eliminated and the increases in plasma levels of these pituitary hormones were blunted. We conclude that while the pituitary hormonal responses to stress might be mediated by several neurohumoral factors, the stress-induced increases in pituitary levels of cyclic AMP in vivo are mediated largely via corticotropin-releasing factor, released from neurons which project from the paraventricular nucleus to the median eminenc
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