In keeping with the programs of periodic hemodialyses and renal transplants, 40 saphenous vein autografts have been performed according to a surgical procedure, which consists of a subcutaneous implantation of a ‘U’ shaped segment obtained from the great saphenous vein of the same patient, anastomosed to an artery and a vein in the forearm or thigh to facilitate the puncture for hemodialysis. We describe an original surgical technique and we evaluate the cardiovascular implications of these flstulae. The following studies were performed before the venous grafting was done: electrocardiogram, vectocardiogram, cardiac X-ray series, arterial pressures, cardiac output, blood volume determination, central venous pressure, and comparative plethysmography. After the surgical procedure, the same studies were repeated supplemented by fistular flow, and angiography, at intervals which varied from 10 to 310 days post-fistula. The postsurgical studies revealed no noteworthy changes of concern, though with an adequate flow to perform dialyses and satisfactory integrity of the venous by-pass. In our series, the magnitude of the hemodynamic changes was not sufficiently severe as to contraindicate the procedure and we concluded that the venous autograft by itself does not harm the patient, rather embodies a valuable help in carrying out the hemodialyses for as long as it is necess