Autologous Transplantation of the Cervical Sympathetic Ganglion into the Parkinsonian BrainCase Report
作者:
Toru Itakura,
Norihiko Komai,
Yukiaki Ryujin,
Yoshitsugu Ooiwa,
Mitsukazu Nakai,
Masayuki Yasui,
期刊:
Neurosurgery
(OVID Available online 1994)
卷期:
Volume 35,
issue 1
页码: 155-158
ISSN:0148-396X
年代: 1994
出版商: OVID
关键词: Neural transplantation;Parkinson's disease;Sympathetic ganglion
数据来源: OVID
摘要:
THE AUTHORS HAVE reported a clinical trial of an autologous cervical sympathetic ganglion transplanted into the brain of a parkinsonian patient. A 45-year-old woman presented with bradykinesia and a gait disturbance for 8 years under L-dopa treatment. The patient underwent stereotactic transplantation of the right stellate ganglion into the right putamen. She showed marked amelioration of bradykinesia and gait disturbance 1 month after the operation, and she was able to conduct her activities of daily living without requiring L-dopa administration. The patient continued to improve gradually until 3 months after the operation. Two years after surgery, the patient functions independently as a housewife. The right hand tremor, however, became slightly worse after the operation, but it was transient. The patient developed a permanent right-sided Horner's syndrome after resection of the cervical sympathetic ganglion. Taken together with our previous data obtained from animal experiments, this case suggests that the autologous cervical sympathetic ganglion can be donor tissue for neural transplantation in Parkinson's disease.
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