Inhibition of alveolar macrophages by pentoxifylline
作者:
JAMES WILLIAMS,
SHAHLA HESHMATI,
SHOKOU TAMADON,
JOSE GUERRA,
期刊:
Critical Care Medicine
(OVID Available online 1991)
卷期:
Volume 19,
issue 8
页码: 1073-1078
ISSN:0090-3493
年代: 1991
出版商: OVID
关键词: xanthine;phosphodiesterase inhibitor;pentoxifylline;leukocyte;macrophage;inflammation;lung;adenosine cyclic;3',5'-monophosphate;neutrophils;alveolar lavage;spectrophotometry
数据来源: OVID
摘要:
Background and MethodsPentoxifylline can inhibit blood leukocyte functions in vitro, and some inflammatory processes in the lung in vivo. Therefore, we examined the effects of pentoxifylline on alveolar macrophage functions in vitro. Alveolar macrophages were harvested from normal rat lungs by airway lavage. The dose-response relationship of varying concentrations of pentoxifylline and in vitro cell functions were examined. Macrophage functions studied included adherence to nylon wool, random (unstimulated) and zymosan-activated serum-stimulated migration through 5 um millipore filters, and superoxide generation induced by zymosan-activated serum as assayed by cytochromecreduction.ResultsPentoxifylline inhibited superoxide generation and stimulated migration (but not random migration or adherence) in a dose-dependent fashion. Statistically significant inhibition was demonstrated at 0.5 mM and 5.0 mM concentrations of pentoxifylline, respectively, for stimulated migration and superoxide generation.ConclusionsPentoxifylline can inhibit some alveolar macrophage functions in vitro. These effects may inhibit some forms of inflammatory lung injury, particularly when iv infusion of high doses of pentoxifylline are utilized. However, potentially adverse effects on inflammatory defense mechanisms must be considered as well.
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