Purpose of the reviewAdverse drug interactions may be the fourth leading cause of death in hospitalized patients. In children and older adults undetected food-drug interactions may lead to serious morbidity and mortality and be misdiagnosed as chronic disease progression. Recent recognition of the effects of certain foods on many drugs metabolized by CYP450 families or drugs susceptible to chelation and adsorption have increased awareness for prevention of food-drug interactions.Recent findingsPolypharmacy, self-medications with non-prescription drugs including herbal remedies, dietary/nutritional supplements, fortified foods, and polymorphism in drug metabolism increase the need to consider food-drug interactions. Improved food processing and analysis have led to overall decreased risk in monoamine oxidase inhibitor regimens with counseling. Drugs may create submarginal nutrient deficiencies with serious consequences, such as diuretics contributing to thiamin deficiency and further cardiac failure. Foods may contain compounds that lead to therapeutic failure, such as calcium-fortified foods producing therapeutic failure and promoting resistance in antibiotic therapy. Poor nutritional status can lead to poor health outcomes.SummaryPrevention of adverse events from food-herb-drug interactions requires clinical monitoring in high-risk regimens and populations. Nutritional status has an important impact on the quality of life as well as appropriate responses to drug therapy. Both diet-drug histories and counseling are needed. As new foods and drugs emerge and more self-medication is promoted, research in the prevention of food-drug interactions is needed.