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Scanning tunneling investigation of DNA structures involved in gene regulation

 

作者: P. Pasero,   C. Blettry,   M. Marilley,   B. Jordan,   S. Granjeaud,   M. Dayez,   A. Humbert,  

 

期刊: Journal of Vacuum Science&Technology B: Microelectronics and Nanometer Structures Processing, Measurement, and Phenomena  （AIP Available online 1994）
卷期: Volume 12, issue 3  

页码: 1521-1525

 

ISSN:1071-1023

 

年代: 1994

 

DOI:10.1116/1.587277

 

出版商: American Vacuum Society

 

关键词: DNA;STM;GENE REGULATION;CURVATURE;COMPARATIVE EVALUATIONS;COMPUTERIZED SIMULATION;ELECTRON MICROSCOPY

 

数据来源: AIP

 

摘要:

Scanning tunneling microscopy (STM) observations made on pBR322 DNA are compared with methods known to give information on DNA intrinsic curvature: polyacrylamide gel retardation, electron microscopy and computer modeling. It is concluded that STM is a powerful method for studying DNA structural features. Moreover, it is the only method to reveal simultaneously nanometric scale detail and long‐range information. Use of STM for analyzing fine DNA structural features in regions involved in gene regulation should make an important contribution to genetics.  

 

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