Initial characterization of whole-cell currents from freshly dissociated corneal keratocytes
作者:
WatskyMitchell A.,
RaeJames L.,
期刊:
Current Eye Research
(Taylor Available online 1992)
卷期:
Volume 11,
issue 2
页码: 127-134
ISSN:0271-3683
年代: 1992
DOI:10.3109/02713689209000063
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The perforated patch technique was utilized to obtain whole-cell currents from freshly dissociated rabbit corneal keratocytes. We describe and provide the initial characterization of two distinct whole cell currents in rabbit keratocytes: a K+-selective delayed rectifier and a voltage-sensitive, tetrodotoxin blockable Na+current. The voltage-sensitive Na+current is of sufficient magnitude to allow us to initiate action potentials when current-clamping the cells. This is the first detailed electrophysiological study of corneal keratocytes.
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