Colchicine Prevents Kidney Transplant Amyloidosis in Familial Mediterranean Fever
作者:
Avi Livneh,
Deborah Zemer,
Bruno Siegal,
Arie Laor,
Ezra Sohar,
Mordechai Pras,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 60,
issue 4
页码: 418-422
ISSN:1660-8151
年代: 1992
DOI:10.1159/000186801
出版商: S. Karger AG
关键词: Colchicine;Kidney transplant;Amyloidosis;Familial Mediterranean fever
数据来源: Karger
摘要:
Twenty-one familial Mediterranean fever (FMF) patients who received a kidney transplant for terminal renal failure due to amyloidosis were studied retrospectively to evaluate the prophylactic effect of colchicine on graft amyloidosis. Proteinuria, highly suggestive of kidney transplant amyloidosis, developed in 11 patients within a median of 3 years after transplantation (range 0.5-10 years). In 10 patients, repeated urinalyses for protein were negative during a median of 5 years after transplantation (range 1-13). Patients who developed proteinuria or transplant amyloidosis received smaller colchicine doses than patients without proteinuria – mean 0.69 (range 0-1) versus 1.53 (range 1-2) milligrams per day (p = 0.0002), suggesting that colchicine prevents or delays development of transplant amyloidosis. This prophylactic effect of colchicine was complete at a dose of 1.5 mg/day or more and absent at a daily dose of 0.5 mg or less. In patients who received 1 mg/day, individual variability in the response to colchicine was observed. We conclude that the development of amyloidosis of the kidney transplant in FMF is inevitable at a colchicine dose lower than 1 mg/day, unpredictable at 1 mg/day and usually preventable with 1.5 mg/day or mor
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