Laboratory studies were conducted to evaluate the efficacy of neem,Azadirachta indicaagainst corn earworm (CEW),Heliocoverpa zeafall armyworm (FAW),Spodoptera frugiperdasugarcane borer (SCB),Diatraea saccharalissouthwestern corn borer (SWCB),Diatraea grandiosellamaize weevil (MW),Sitophilus zeamaisand larger grain borer (LGB),Prostephanus truncatus.Neem seed powder at the rate of 5 g and 10 g, and neem seed oil at the rate of 1 ml per kg of meridic diets, were incorporated into the diet of CEW, FAW, SCB and SWCB. Maize grain was treated with 5 and 10 ml neem seed oil per kg of grain and infested with adult MW and LGB. The presence of neem seed powder and neem seed oil in the diets significantly reduced the survival and growth of CEW, FAW, SCB and SWCB. Neem oil also had significant effects on the survival of MW. In the case of LGB the effects of neem oil, however, were not profound. Results indicate that neem has good potential to be used as a control agent for the CEW, FAW, SCB, SWCB and MW.