Risk ranges for various endpoints following exposure to 2,3,7,8-TCDD
作者:
Chris Portier,
期刊:
Food Additives & Contaminants
(Taylor Available online 2000)
卷期:
Volume 17,
issue 4
页码: 335-346
ISSN:0265-203X
年代: 2000
DOI:10.1080/026520300283405
出版商: Taylor & Francis Group
关键词: Cancer Endpoints Curve Fitting Dose-RESPONSE Mechanistic Models Non-CANCER Endpoints Non-LINEARITY
数据来源: Taylor
摘要:
Conducting a dose-response analysis for an environmental contaminant requires a careful evaluation of most of the available data focusing on both the magnitude of the effect and the possible ranges of dose-response shapes which fit the data. This paper calculates potency values (1% response exposures) for human and animal data on cancer, non-cancer and biological effect endpoints for TCDD and finds that a reasonable estimate for 1% excess cancer would be between 1 and 50 pg/kg/day. The paper also evaluates the adequacy of linear and non-linear models for fitting these data and concludes that the assumption of a threshold dose-response is not fully supported by these data.
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