Determination of Apomorphine in Tablets Using High Performance Liquid Chromatography with Electrochemical Detection
作者:
RobertV. Smith,
DavidW. Humphrey,
期刊:
Analytical Letters
(Taylor Available online 1981)
卷期:
Volume 14,
issue 8
页码: 601-613
ISSN:0003-2719
年代: 1981
DOI:10.1080/00032718108055473
出版商: Taylor & Francis Group
关键词: apomorphine;HPLC;tablets;electrochemical detection
数据来源: Taylor
摘要:
A rapid and selective method using high performance liquid chromatography with electrochemical detection is described for the determination of apomorphine in tablets. Tablet mixes were dissolved in a standard volume of mobile phase containing the internal standard, N-n-propylnorapomorphine. Separation was achieved on a μ-phenyl column using methanol-acetonitrile-0.05M KH2PO4(5:15:80) as mobile phase. The eluted compounds were detected with a sandwich-type electrochemical detector employing a glassy carbon working electrode and operated at 0.5V. Satisfactory accuracy and precision were obtained during analyses of tablets containing apomorphine.
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