Immunoglobulin A Nephropathy in a Renal Allograft of a Black Transplant Recipient
作者:
Susan Francisco,
Barry M. Wall,
Robert Cooke,
期刊:
American Journal of Nephrology
(Karger Available online 1992)
卷期:
Volume 12,
issue 1-2
页码: 121-125
ISSN:0250-8095
年代: 1992
DOI:10.1159/000168431
出版商: S. Karger AG
关键词: Immunoglobulin A nephropathy;Renal transplantation;Hepatitis C
数据来源: Karger
摘要:
Although IgA nephropathy (IgA N) is reportedly the most common form of primary glomerulonephritis worldwide, there is a very low incidence of IgA N in Black Americans, and IgA N in Black patients with renal allografts has not been reported. In this report, we present the case of a Black patient with end-stage renal disease presumed secondary to hypertensive nephrosclerosis who developed nephrotic range proteinuria due to IgA N in a cadaveric renal allograft 2 years following transplantation. Biopsy of the allograft in the immediate post-transplantation period had revealed no evidence of IgA N. Chronic active hepatitis related to hepatitis C preceded the development of proteinuria by approximately 1 year, raising the possibility that IgA N in the renal allograft was secondary to the liver disease. The clinical and histological features of primary IgA N and IgA N secondary to liver diseases are discussed.
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