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Synthesis of chiral N-protected amino acid esters by the use of UNCAs

 

作者: P.Chevallet,   J.-A.Fehrentz,   K.Kiec-Kononowicz,   C.Devin,   J.Castel,   A.Loffet,   J.Martinez,  

 

期刊: Letters in Peptide Science  （Springer Available online 2004）
卷期: Volume 2, issue 5  

页码: 297-300

 

ISSN:0929-5666

 

年代: 2004

 

DOI:10.1007/BF00142242

 

出版商: Springer_Netherlands-Dordrecht

 

数据来源: Springer

 

摘要:

An easy synthesis of N-protected amino acid esters, includingtert-butyl esters, is described by the use of urethane N-protected carboxyanhydrides (UNCAs). Treating UNCAs withtert-butanol in the presence of potassium bicarbonate at 45°C yielded the corresponding N-protected amino acidtert-butyl esters in a very simple way. Benzyloxycarbonyl andtert-butyloxycarbonyl N-protected amino acidtert-butyl esters have been obtained by this procedure. Once more, this reaction showed the great reactivity of UNCAs

 

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