Henoglobin S-O ARAB-α-Thalassenia Globin Biosynmesis and Clinical Picture
作者:
BallasSmir K.,
AtwaterJean,
BurkaEdward R.,
期刊:
Hemoglobin
(Taylor Available online 1977)
卷期:
Volume 1,
issue 7
页码: 651-662
ISSN:0363-0269
年代: 1977
DOI:10.3109/03630267708999172
出版商: Taylor&Francis
数据来源: Taylor
摘要:
A 22 year old American negro with mil.d anemia was found to be triply heterozygous for henoglobin S. hemoglobin 0 Arab and alpha thalasseaia. Hemoglobin A was not detected in the subject's hemolysate. The alpha thalasseaia gene was expressed by anα/non-αsynthesis ratio of 0.71à0.07 and was equally unbalanced in the peripheral blood and the bone marrow. The total radioactivity of the abnormal chains was equal, indicating equal rates of transcription and translation of the abnormal structural genes. Since the rate of synthesis of BSand B0was equal to the proportions of these abnormal chains in the peripheral blood, the abnormal gene products were equally stable. The mildness of the anemia, compared to that of the other reported S-O Arab double heterozygotes, may be due to the moderating influence of the alpha thal gene.
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