The effects of long‐term hyperinsulinaemia on insulin sensitivity in rats
作者:
A. HOLMáNG,
E. JENNISCHE,
P. BJÖRNTORP,
期刊:
Acta Physiologica Scandinavica
(WILEY Available online 1995)
卷期:
Volume 153,
issue 1
页码: 67-73
ISSN:0001-6772
年代: 1995
DOI:10.1111/j.1748-1716.1995.tb09835.x
出版商: Blackwell Publishing Ltd
关键词: adipose tissue;capillary density;glyscogen synthesis;hyperinsulinaemia;rats;skeletal muscle
数据来源: WILEY
摘要:
The effects of long‐term exposure (7 wk) to hyperinsulinaemia on insulin sensitivity were studied in female rats. The rats were made hyperinsulinaemic by implantation of osmotic minipumps that were changed once a week. Elevated adrenergic activity and secretion of glucocorticoids were controlled by another minipump with propranolol and adrenalectomy with corticosterone substitution, respectively. This resulted in hyperinsulinaemia and moderate hypoglycaemia, the latter probably counteracted by overeating and increased glucagon secretion, as indicated by increased body weight and lower liver glycogen contents, respectively. Euglycaemic, hyperinsulinaemic clamp measurements showed a significantly higher glucose disposal rate (P<0.05) in the hyperinsulinaemic rats 18.8± 1.1 mg kg‐1min‐1compared with the control groups 14.6±0.4 and 15.4±0.9 mg kg‐1min‐1. Insulin stimulation of 2‐deoxyglucose as well as glycogen synthesis was measured in the extensor digitorum longus muscle, the red and white part of the gastrocnemius, the soleus muscle, the liver and in parametrial, retroperitoneal, and inguinal adipose tissue. No differences were found between the groups in the insulin response of the 2‐deoxyglucose uptake. Glycogen synthesis was significantly elevated in all muscles in the insulin treated compared with the control rats but no differences were found in the liver. Capillary density was significantly elevated per unit muscle surface area in the soleus and extensor digitorum longus muscles of the insulin‐exposed rats. These results suggest that long‐term exposure to insulin is followed by increased insulin sensitivity, apparently localized to the insulin regulation of glycogen synthesis in muscles. Muscle capillary density is
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