Anti-Inflammatory Activity of Croconazole, a Broad-Spectrum Antimycotic Agent, in the Arachidonic Acid-Induced Mouse Ear Swelling Test
作者:
Dierk Steinmann,
Joachim Barth,
Gottfried Wozel,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1995)
卷期:
Volume 8,
issue 4
页码: 211-214
ISSN:1660-5527
年代: 1995
DOI:10.1159/000211349
出版商: S. Karger AG
关键词: Arachidonic acid metabolism;Swelling test;mouse ear;Croconazole;Antimycotic agent;Anti-inflammatory properties
数据来源: Karger
摘要:
Investigations on croconazole, a novel imidazole compound, suggested antiphlogistic properties in vitro. Hence, its anti-inflammatory capacity was tested in vivo using the arachidonic acid-induced mouse ear swelling test, which is a suitable model for screening inhibitors of the lipoxygenase and/or the cyclooxygenase. Topical application of croconazole (1%/ 0.01 %) to the mouse ear induced a maximal inhibition of edema (inhibition: 39%/33%; p = 0.01) which was as strong as the reference nordihydroguaiaretic acid (inhibition: 38.9%; p = 0.01). These results justify further investigations on croconazole to study potential inhibitory effects on proinflammatory arachidonic acid metabolites.
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