Case ReportAlternation Therapy with Antileukemic Agents and Recombinant Human Granulocyte Colony‐Stimulating Factor for RAEB in Transformation
作者:
SEIJI IRIE,
HIDEMI OGURA,
SHIN-ICHIRO OKAMOTO,
ARINOBU TOJO,
KENZABURO TANI,
KENJI IKEBUCHI,
NORIHARU SATOH,
KEIYA OZAWA,
SHIGETAKA ASANO,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1992)
卷期:
Volume 303,
issue 5
页码: 316-318
ISSN:0002-9629
年代: 1992
出版商: OVID
关键词: Alternation therapy;Antileukemic agents;Recombinant human granulocyte colony-stimulating factor
数据来源: OVID
摘要:
Under the assumption that in some patients with refractory anemia with excess of blasts (RAEB), the abnormal clones might be less responsive to granulocyte colony-stimulating factor than normal clones, the authors tried alternation therapy with a recombinant form of this factor (rhG-CSF) and antileukemic agents in the treatment of two patients with RAEB in transformation. After repetition of the short-cycled alternation therapy, the hematologic findings of both patients were completely normalized and have remained so without any adverse side effects under the continuation of this therapy for more than 5 months. Judging from our clinical experience, the alternation therapy may be a new efficient therapeutic strategy for RAEB and some types of slowly progressive leukemia.
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